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Trigonella foenum-graecum and Lespedeza cuneata - a new herbal medicine to treat testosterone deficiency?

In a nutshell

This study investigated if a mixed herbal extract of Trigonella foenumgraecum and Lespedeza cuneata (TFGL) could improve testosterone deficiency. They found that TFGL improved testosterone levels in men with testosterone deficiency.

Some background

Testosterone is a male sex hormone. It has a number of functions in the body. This includes the production of sperm. Testosterone deficiency syndrome (TDS) is caused by a lack of testosterone production. TDS can be treated with regular injections of testosterone. This is called testosterone replacement therapy (TRT).

There are some side effects associated with TRT. Some studies suggest it may increase the risk of developing conditions such as cancer. Although there is not enough evidence to support this, some doctors and patients are reluctant to choose TRT.

Some herbal medicines have been shown to improve testosterone levels. Trigonella foenumgraecum (TFG), also known as fenugreek, is an extract from the seed of an Indian plant. TFG may increase the levels of testosterone in the body. The mechanism of action is not fully understood. It is unclear if TFG is a suitable treatment for TDS.

Methods & findings

This study included 88 men with TDS. Half of the patients were assigned to a treatment with 400 milligrams daily of a mixed extract of TFG and Lespedeza cuneata (TGFL). The other half received a placebo (inactive drug). These were the control group. The study lasted 8 weeks. Testosterone levels and TDS symptoms were measured. Blood tests were also performed to measure cholesterol and other fats involved with testosterone production.

Patients taking TGDL showed an improvement in TDS symptoms at 4 and 8 weeks. The level of testosterone was increased in TGFL patients. TGFL patients also improved levels of cholesterol and fats associated with testosterone production. TGFL was well tolerated and no serious adverse events were reported.

Methods & findings
The bottom line

The authors concluded that TFGL improved testosterone levels.

The fine print

This study included a relatively small number of patients. Larger studies are needed to investigate the effects of TGFL. The long-term safety of TGFL also needs further investigation.

What’s next?

If you have any questions about testosterone deficiency and fertility please discuss this with your physician.

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Published By: The world journal of men’s health
Date: Nov 11, 2020
Original Title: Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

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